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KMID : 1161420100130010142
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Journal of Medicinal Food
2010 Volume.13 No. 1 p.142 ~ p.148
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Medicinal Mushroom Ganoderma lucidum (Leyss: Fr) Karst. Triggers Immunomodulatory Effects and Reduces Nitric Oxide Synthesis in Mice
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Rubel Rosalia
Santa Herta S. Dalla
Bonatto Sandro J. R.
Bello Sergio
Fernandes Luiz Claudio
Di Bernardi Raffaello
Gern Juliana
Santos Cid Aimbire M.
Soccol Carlos Ricardo
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Abstract
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This study investigated the effect of Ganoderma lucidum supplementation on lymphocytes and peritoneal macrophages from mice. Our results show that G. lucidum in vivo was able to increase interferon-γ (IFN-γ) concentration but reduced CD3+ and CD8+ spleen lymphocytes. Ex vivo, IFN-γ; and interleukin-10 levels were increased and the tumor necrosis factor-α (TNF-α) level was reduced by peritoneal macrophages from mice fed with G. lucidum. In the absence of stimuli nitric oxide production was reduced in mice fed with G. lucidum, and with lipopolysaccharide stimulation nitric oxide production was increased but was lower than control values (P?
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KEYWORD
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cytokines, edible mushroom, immunomodulation, Reishi, tumor necrosis factor-α
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